Advances in droplet-based digital microfluidic biochips (DMFBs) have led to the emergence of biochips for automating laboratory procedures in biochemistry and molecular biology. These devices enable the precise control of microliter of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and integrate various bioassay operations, such as sample preparation, analysis, separation, and detection. To meet the challenges of increasing design complexity and precision, the interplay between hardware and software through sensor-based cyberphysical integration will be involved to build DMFBs effectively. This talk offers attendees an opportunity to bridge the semiconductor ICs/system industry with the biomedical and pharmaceutical industries. The talk will first describe emerging applications in biology and biochemistry that can benefit from advances in electronic “biochips”. The presenter will next describe technology platforms for accomplishing “biochemistry on a chip”, and introduce the audience to microarrays and fluidic actuation methods based on microfluidics. The droplet-based "digital" microfluidic platform based on electrowetting will be described in considerable detail. Next, the presenter will describe fabrication techniques for digital microfluidic biochips, followed by computer-aided design, design-for-testability, cyberphysical integration, and reconfiguration aspects of chip/system design. Synthesis algorithms and methods will be presented to map behavioral descriptions to a digital microfluidic platform, and generate an optimized schedule of bioassay operations, chip layout, and droplet-flow paths. In this way, the audience will see how a “biochip compiler” can translate protocol descriptions provided by an end user (e.g., a chemist or a nurse at a doctor’s clinic) to a set of optimized and executable fluidic instructions that will run on the underlying digital microfluidic platform.